研究業績

原著論文

2023年

• "Construction of a T cell receptor signaling range for spontaneous development of autoimmune disease. "
  Atsushi Tanaka, Shinji Maeda, Takashi Nomura, Mara Anais Llamas-Covarrubias, Satoshi Tanaka, Lin Jin, Ee Lyn Lim, Hiromasa Morikawa, Yohko Kitagawa, Shuji Akizuki, Yoshinaga Ito, Chihiro Fujimori, Keiji Hirota, Tosei Murase, Motomu Hashimoto, Junichi Higo, Rose Zamoyska, Ryuzo Ueda, Daron M Standley, Noriko Sakaguchi, Shimon Sakaguchi
  The Journal of experimental medicine 220, 2 (2023).

2021年

• "Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis. "
  Mathewson ND, Ashenberg O, Tirosh I, Gritsch S, Perez EM, Marx S, Jerby-Arnon L, Chanoch-Myers R, Hara T, Richman AR, Ito Y, Pyrdol J, Friedrich M, Schumann K, Poitras MJ, Gokhale PC, Gonzalez Castro LN, Shore ME, Hebert CM, Shaw B, Cahill HL, Drummond M, Zhang W, Olawoyin O, Wakimoto H, Rozenblatt-Rosen O, Brastianos PK, Liu XS, Jones PS, Cahill DP, Frosch MP, Louis DN, Freeman GJ, Ligon KL, Marson A, Chiocca EA, Reardon DA, Regev A, Suvà ML, Wucherpfennig KW.
  Cell 184, 5 (2021).
• "CARM1 Inhibition Enables Immunotherapy of Resistant Tumors by Dual Action on Tumor Cells and T Cells. "
  Sushil Kumar, Zexian Zeng, Archis Bagati, Rong En Tay, Lionel A Sanz, Stella R Hartono, Yoshinaga Ito, Fieda Abderazzaq, Elodie Hatchi, Peng Jiang, Adam N R Cartwright, Olamide Olawoyin, Nathan D Mathewson, Jason W Pyrdol, Mamie Z Li, John G Doench, Matthew A Booker, Michael Y Tolstorukov, Stephen J Elledge, Frédéric Chédin, X Shirley Liu, Kai W Wucherpfennig
  Cancer discovery 11, 8, 2050-2071 (2021).

2020年

• "Inhibition of MICA and MICB Shedding Elicits NK-Cell-Mediated Immunity against Tumors Resistant to Cytotoxic T Cells. "
  Lucas Ferrari de Andrade, Sushil Kumar, Adrienne M Luoma, Yoshinaga Ito, Pedro Henrique Alves da Silva, Deng Pan, Jason W Pyrdol, Charles H Yoon, Kai W Wucherpfennig
  Cancer immunology research 8, 6, 769-780 (2020).
• "Hdac3 is an epigenetic inhibitor of the cytotoxicity program in CD8 T cells."
  Rong En Tay, Olamide Olawoyin, Paloma Cejas, Yingtian Xie, Clifford A Meyer, Yoshinaga Ito, Qing Yu Weng, David E Fisher, Henry W Long, Myles Brown, Hye-Jung Kim, Kai W Wucherpfennig
  The Journal of experimental medicine 217, 7 (2020).

2019年

• "Strain-Specific Manifestation of Lupus-like Systemic Autoimmunity Caused by Zap70 Mutation. "
  Matsuo T, Hashimoto M, Sakaguchi S, Sakaguchi N, Ito Y, Hikida M, Tsuruyama T, Sakai K, Yokoi H, Shirakashi M, Tanaka M, Ito H, Yoshifuji H, Ohmura K, Fujii T, Mimori T
  Journal of immunology 202, 11, 3161-3172 (2019).
• "Discovery of specialized NK cell populations infiltrating human melanoma metastases. "
  Lucas Ferrari de Andrade, Yuheng Lu, Adrienne Luoma, Yoshinaga Ito, Deng Pan, Jason W Pyrdol, Charles H Yoon, Guo-Cheng Yuan, Kai W Wucherpfennig
  JCI insight 4, 23 (2019).

2018年

• "Autoimmune Th17 Cells Induced Synovial Stromal and Innate Lymphoid Cell Secretion of the Cytokine GM-CSF to Initiate and Augment Autoimmune Arthritis. "
  Hirota K, Hashimoto M, Ito Y, Matsuura M, Ito H, Tanaka M, Watanabe H, Kondoh G, Tanaka A, Yasuda K, Kopf M, Potocnik AJ, Stockinger B, Sakaguchi N, Sakaguchi S
  Immunity 48, 6, 1220-1232 (2018).
• "Antibody-mediated inhibition of MICA and MICB shedding promotes NK cell-driven tumor immunity. "
  Lucas Ferrari de Andrade, Rong En Tay, Deng Pan, Adrienne M Luoma, Yoshinaga Ito, Soumya Badrinath, Daphne Tsoucas, Bettina Franz, Kenneth F May Jr, Christopher J Harvey, Sebastian Kobold, Jason W Pyrdol, Charles Yoon, Guo-Cheng Yuan, F Stephen Hodi, Glenn Dranoff, Kai W Wucherpfennig
  Science 359, 6383, 1537-1542 (2018).
• "Rapid CLIP dissociation from MHC II promotes an unusual antigen presentation pathway in autoimmunity. "
  Yoshinaga Ito, Orr Ashenberg, Jason Pyrdol, Adrienne M Luoma, Orit Rozenblatt-Rosen, Matan Hofree, Elena Christian, Lucas Ferrari de Andrade, Rong En Tay, Luc Teyton, Aviv Regev, Stephanie K Dougan, Kai W Wucherpfennig
  The Journal of experimental medicine 215, 10, 2617-2635 (2018).

2017年

• "Cell-contact-dependent activation of CD4+ T cells by adhesion molecules on synovial fibroblasts. "
  Mori M, Hashimoto M, Matsuo T, Fujii T, Furu M, Ito H, Yoshitomi H, Hirose J, Ito Y, Akizuki S, Nakashima R, Imura Y, Yukawa N, Yoshifuji H, Ohmura K, Mimori T
  Modern rheumatology 27, 3, 448-456 (2017).

2016年

• "Dysbiosis Contributes to Arthritis Development via Activation of Autoreactive T Cells in the Intestine. "
  Maeda Y, Kurakawa T, Umemoto E, Motooka D, Ito Y, Gotoh K, Hirota K, Matsushita M, Furuta Y, Narazaki M, Sakaguchi N, Kayama H, Nakamura S, Iida T, Saeki Y, Kumanogoh A, Sakaguchi S, Takeda K
  Arthritis & rheumatology 68, 11, 2646-2661 (2016).

2014年

• "Detection of T cell responses to a ubiquitous cellular protein in autoimmune disease. "
  Ito Y, Hashimoto M, Hirota K, Ohkura N, Morikawa H, Nishikawa H, Tanaka A, Furu M, Ito H, Fujii T, Nomura T, Yamazaki S, Morita A, Vignali DA, Kappler JW, Matsuda S, Mimori T, Sakaguchi N, Sakaguchi S
  Science 346, 6207, 363-368 (2014).

2012年

• "T Cell Receptor Stimulation-Induced Epigenetic Changes and Foxp3 Expression Are Independent and Complementary Events Required for Treg Cell Development "
  Naganari Ohkura, Masahide Hamaguchi, Hiromasa Morikawa, Kyoko Sugimura, Atsushi Tanaka, Yoshinaga Ito, Motonao Osaki, Yoshiaki Tanaka, Riu Yamashita, Naoko Nakano, Jochen Huehn, Hans Joerg Fehling, Tim Sparwasser, Kenta Nakai, Shimon Sakaguchi
  IMMUNITY 37, 5, 785-799 (2012).

2011年

• "Overexpression of a Minimal Domain of Calpastatin Suppresses IL-6 Production and Th17 Development via Reduced NF-kappa B and Increased STAT5 Signals "
  Mikiko Iguchi-Hashimoto, Takashi Usui, Hajime Yoshifuji, Masakazu Shimizu, Shio Kobayashi, Yoshinaga Ito, Kosaku Murakami, Aoi Shiomi, Naoichiro Yukawa, Daisuke Kawabata, Takaki Nojima, Koichiro Ohmura, Takao Fujii, Tsuneyo Mimori
  PLOS ONE 6, 10, e27020 (2011).

2010年

• "Graded Attenuation of TCR Signaling Elicits Distinct Autoimmune Diseases by Altering Thymic T Cell Selection and Regulatory T Cell Function "
  Satoshi Tanaka, Shinji Maeda, Motomu Hashimoto, Chihiro Fujimori, Yoshinaga Ito, Shin Teradaira, Keiji Hirota, Hiroyuki Yoshitomi, Tomoya Katakai, Akira Shimizu, Takashi Nomura, Noriko Sakaguchi, Shimon Sakaguchi
  JOURNAL OF IMMUNOLOGY 185, 4, 2295-2305 (2010).

2009年

• "Gamma/Delta T Cells Are the Predominant Source of Interleukin-17 in Affected Joints in Collagen-Induced Arthritis, but Not in Rheumatoid Arthritis "
  Yoshinaga Ito, Takashi Usui, Shio Kobayashi, Mikiko Iguchi-Hashimotol, Hiromu Ito, Hiroyuki Yoshitomi, Takashi Nakamura, Masakazu Shimizu, Daisuke Kawabata, Naoichiro Yukawa, Motomu Hashimoto, Noriko Sakaguch, Shimon Sakaguchi, Hajime Yoshifuji, Takaki Nojima, Koichiro Ohmura, Takao Fujii, Tsuneyo Mimori
  ARTHRITIS AND RHEUMATISM 60, 8, 2294-2303 (2009).

2007年

• "Severe subcutaneous generalized edema in a patient with dermatomyositis "
  Yoshinaga Ito, Daisuke Kawabata, Naoichiro Yukawa, Hajime Yoshifuji, Takashi Usui, Masao Tanaka, Takao Fujii, Tsuneyo Mimori
  Modern Rheumatology 17, 2, 171-173 (2007).